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MRC Supremo protocol

SUPREMO Protocol version 29.1 11th June 2019 , MREC Ref:05/S0501/106 (PDF) [1Mb]

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Radiotherapy QA programme (external website)

Supremo Site Work Instructions, Version 6.0 October 2020 (PDF) [921 Kb]

Recent Publications

Radiotherapy after mastectomy can be avoided | News | The University of Edinburgh, November 2025 (external website)

Access the full publication via: Ten-Year Survival after Postmastectomy Chest-Wall Irradiation in Breast Cancer | New England Journal of Medicine, November 2025 (external website)

Quality of Life after post mastectomy radiotherapy in patients with intermediate-risk breast cancer(SUPRMO) ; 2 year follow up results of a randomised controlled trial.  Lancet Oncology Oct 15 2018. (external website)

Editorial, European Journal of Surgical Oncology, April 2017 (external website)

Thomas, J.S., Hanby, A.M., Russell, N. et al. The BIG 2.04 MRC/EORTC SUPREMO Trial: pathology quality assurance of a large phase 3 randomised international clinical trial of postmastectomy radiotherapy in intermediate-risk breast cancer. Breast Cancer Res Treat 163, 63–69 (2017). https://doi.org/10.1007/s10549-017-4145-4 (external website)

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